Warning: require_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-includes/load.php on line 392 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-settings.php on line 85 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-settings.php on line 86 Warning: require_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-includes/pomo/mo.php on line 10 Warning: require_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-includes/pomo/translations.php on line 10 Warning: require_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-includes/pomo/mo.php on line 11 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-settings.php on line 103 Warning: require(): Unable to allocate memory for pool. in 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/var/www/vhost/sidalava.org/home/html/wp-settings.php on line 118 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-settings.php on line 119 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-settings.php on line 120 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-settings.php on line 121 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-settings.php on line 122 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-settings.php on line 123 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-settings.php on line 124 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-settings.php on line 125 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-settings.php on line 126 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-settings.php on line 127 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-settings.php on line 128 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-settings.php on line 129 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-settings.php on line 130 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-settings.php on line 131 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-settings.php on line 132 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-settings.php on line 133 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-settings.php on line 134 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-includes/script-loader.php on line 25 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-includes/script-loader.php on line 28 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-includes/script-loader.php on line 31 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-includes/script-loader.php on line 34 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-includes/script-loader.php on line 37 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-settings.php on line 135 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-settings.php on line 136 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/buddypress-group-documents/index.php on line 60 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/buddypress-group-documents/index.php on line 61 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/buddypress-group-documents/index.php on line 62 Warning: include_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-settings.php on line 196 Warning: include_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-settings.php on line 196 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/buddypress-restrict-group-creation/bp-restrict-group-creation-loader.php on line 28 Warning: include_once(): Unable to 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38 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/buddypress/bp-core.php on line 39 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/buddypress/bp-core.php on line 40 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/buddypress/bp-core.php on line 41 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/buddypress/bp-core.php on line 42 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/buddypress/bp-core.php on line 46 Warning: include(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/buddypress/bp-loader.php on line 26 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/buddypress/bp-activity.php on line 9 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/buddypress/bp-activity.php on line 10 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/buddypress/bp-activity.php on line 11 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/buddypress/bp-blogs.php on line 9 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/buddypress/bp-blogs.php on line 10 Warning: include(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/buddypress/bp-loader.php on line 38 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/buddypress/bp-friends.php on line 9 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/buddypress/bp-friends.php on line 10 Warning: include(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/buddypress/bp-loader.php on line 42 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/buddypress/bp-groups.php on line 9 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/buddypress/bp-groups.php on line 10 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/buddypress/bp-groups.php on line 11 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/buddypress/bp-groups.php on line 12 Warning: include(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/buddypress/bp-loader.php on line 46 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/buddypress/bp-messages.php on line 9 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/buddypress/bp-messages.php on line 10 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/buddypress/bp-messages.php on line 11 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/buddypress/bp-messages.php on line 12 Warning: include(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/buddypress/bp-loader.php on line 50 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/buddypress/bp-xprofile.php on line 8 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/buddypress/bp-xprofile.php on line 9 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/buddypress/bp-xprofile.php on line 10 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/buddypress/bp-xprofile.php on line 11 Warning: require(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/buddypress/bp-xprofile.php on line 12 Warning: include_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-settings.php on line 196 Warning: require_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/contact-form-7/wp-contact-form-7.php on line 69 Warning: require_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/contact-form-7/settings.php on line 42 Warning: require_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/contact-form-7/settings.php on line 43 Warning: require_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/contact-form-7/settings.php on line 44 Warning: require_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/contact-form-7/settings.php on line 45 Warning: require_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/contact-form-7/settings.php on line 46 Warning: require_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/contact-form-7/settings.php on line 47 Warning: require_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/contact-form-7/settings.php on line 52 Warning: include_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-settings.php on line 196 Warning: include(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/more-fields/more-fields.php on line 45 Warning: include(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/more-fields/more-fields.php on line 47 Warning: include(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/more-fields/more-fields.php on line 48 Warning: include(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/more-fields/more-fields.php on line 49 Warning: include(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/more-fields/more-fields.php on line 50 Warning: include_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-settings.php on line 196 Warning: include_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-settings.php on line 196 Warning: require_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/nextgen-gallery/nggallery.php on line 291 Warning: require_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/nextgen-gallery/nggallery.php on line 292 Warning: require_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/nextgen-gallery/nggallery.php on line 293 Warning: require_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/nextgen-gallery/nggallery.php on 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require_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/nextgen-gallery/nggallery.php on line 302 Warning: require_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/nextgen-gallery/nggallery.php on line 303 Warning: require_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/nextgen-gallery/nggallery.php on line 313 Warning: require_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/nextgen-gallery/nggallery.php on line 314 Warning: require_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/nextgen-gallery/nggallery.php on line 315 Warning: include_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/nextgen-gallery/nggallery.php on line 316 Warning: include_once(): Unable 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Warning: require_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/qtranslate/qtranslate.php on line 446 Warning: require_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/qtranslate/qtranslate.php on line 447 Warning: require_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/qtranslate/qtranslate.php on line 451 Warning: require_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/tdo-mini-forms/tdomf.php on line 564 Warning: require_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/tdo-mini-forms/tdomf.php on line 569 Warning: require_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/tdo-mini-forms/tdomf.php on line 680 Warning: require_once(): Unable to allocate 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/var/www/vhost/sidalava.org/home/html/wp-content/plugins/tdo-mini-forms/tdomf.php on line 695 Warning: require_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/tdo-mini-forms/tdomf.php on line 696 Warning: require_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/tdo-mini-forms/tdomf.php on line 697 Warning: require_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/tdo-mini-forms/tdomf.php on line 698 Warning: require_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/tdo-mini-forms/tdomf.php on line 699 Warning: require_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/tdo-mini-forms/tdomf.php on line 700 Warning: require_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/tdo-mini-forms/tdomf.php on line 701 Warning: require_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/tdo-mini-forms/tdomf.php on line 712 Warning: require_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/tdo-mini-forms/include/tdomf-widget-functions.php on line 25 Warning: require_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/tdo-mini-forms/include/tdomf-widget-functions.php on line 25 Warning: require_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/tdo-mini-forms/include/tdomf-widget-functions.php on line 25 Warning: require_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/tdo-mini-forms/include/tdomf-widget-functions.php on line 25 Warning: require_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/tdo-mini-forms/include/tdomf-widget-functions.php on line 25 Warning: require_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-includes/functions.php on line 3309 Warning: include_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/contact-form-7/settings.php on line 80 Warning: include_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/contact-form-7/settings.php on line 80 Warning: include_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/contact-form-7/settings.php on line 80 Warning: include_once(): Unable to allocate memory for pool. in /var/www/vhost/sidalava.org/home/html/wp-content/plugins/contact-form-7/settings.php on line 80 Warning: include_once(): Unable to allocate 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Inicio > Noticias > VIH > Nuevos hallazgos muestran…

Nuevos hallazgos muestran cómo algunas células se protegen del VIH

Una proteína, que protege a algunas de nuestras células inmunes de la forma más común y virulenta del VIH, funciona privando al virus de los bloques moleculares que necesita para replicarse, según un estudio publicado en ‘Nature Immunology’.

El hallazgo proviene de un equipo internacional de investigadores, que incluye a científicos de la Universidad de Rochester, el Centro Médico Langone, de la Universidad de Nueva York, varias instituciones en Francia, y un estudiante graduado –refugiado político de África– que ahora está trabajando en el laboratorio de Rochester, con la intención de ayudar a su pueblo, devastado por la epidemia del VIH.

Mientras que los investigadores esperan que este trabajo, algún día, ayude a desarrollar fármacos anti-VIH más efectivos, mediante el aumento de su potencia contra el virus, también están entusiasmados con sus implicaciones sobre el conocimiento de otros patógenos, como el virus del herpes, que utiliza la misma maquinaria dentro de nuestras células que el VIH utiliza para replicarse.

“Estos hallazgos podrían explicar por qué ciertos medicamentos contra el VIH utilizados en la actualidad son más eficaces en algunas circunstancias que en otras”, afirma el doctor Baek Kim, profesor de Microbiología e Inmunología de la Universidad de Rochester, y uno de los autores del trabajo.

La investigación se centró en una proteína conocida como SAMHD1, que se encuentra en las células blancas de la sangre –conocidas como macrófagos– y en células relacionadas conocidas como células dendríticas.

El año pasado, los científicos descubrieron que esta molécula hace que sea difícil, para el VIH-1, infectar a los macrófagos -células que se especializan en devorar y destruir a invasores, como los virus. Ahora, los investigadores han descubierto que la molécula corta la línea de suministro de materia prima que el VIH necesita para crear ADN y replicarse. Esa materia prima, dNTP, comprende los bloques de construcción de ADN y, sin ella, el VIH no puede recrear su ADN en nuestras células.

El equipo observó, también, que SAMHD1 destruye la mayor parte de estos bloques de construcción, por lo que hace casi imposible que el VIH-1 se replique a sí mismo allí donde reside la SAMHD1 -en los macrófagos. Así, en vez de replicarse, el VIH-1 utiliza el macrófago como un refugio seguro, sobreviviendo en los pacientes durante años, ya que esquiva el sistema inmunológico y los fármacos diseñados para acabar con él.

Es, en gran parte, gracias a su capacidad para esconderse en el cuerpo, que el VIH es capaz de sobrevivir durante décadas y, finalmente, asaltar el sistema inmunológico del cuerpo. Una posibilidad es que el virus –cuando se enfrenta a una escasez de materias primas– ponga su capacidad de mutación a funcionar a toda marcha, creando más mutaciones en un esfuerzo por eludir la vía bloqueada por SAMHD1 (tales mutaciones constantes son las características del VIH que lo hacen tan difícil de tratar).

“Tiene sentido que un mecanismo como este se active en los macrófagos”, explica Kim, “los macrófagos, literalmente, comen organismos peligrosos, y no desean que estos organismos dispongan de la maquinaria celular necesaria para replicarse, y los macrófagos, por sí mismos, no la necesitan, porque no se replican”.

El investigador concluye que “este trabajo sugiere nuevas formas para atacar la replicación del virus en los macrófagos, una población de células muy importante que sirve como reservorio clave de la infección por el virus, que colabora con la enfermedad inducida por el VIH”.

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